Photodynamic therapy-induced Acute Exudative Maculopathy (PAEM) in CCH

Here is a summary of the key points from the article in bullet form:

- Objective: To describe the incidence, features, and clinical outcomes of photodynamic therapy-induced acute exudative maculopathy (PAEM) in patients with circumscribed choroidal hemangioma (CCH).
  
- Methods:
  - Prospective case series of 10 patients with CCH treated with standard-fluence photodynamic therapy (PDT).
  - Patients underwent best-corrected visual acuity (BCVA) testing and swept-source optical coherence tomography (OCT) before PDT, 3 days after, and 1 month after treatment.
  - PAEM was defined as an increase ≥50 μm in subretinal fluid (SRF) or intraretinal fluid (IRF), or the appearance of fibrin 3 days after PDT.

- Results:
  - Incidence of PAEM: 7 out of 10 patients (70%) developed PAEM.
  - Types of PAEM: 5 patients had increased IRF, 2 had increased SRF, and 1 had abundant fibrin.
  - Visual Acuity: Median BCVA was stable at 1 month (64 letters) compared to baseline (57.5 letters).
  - Central Retinal Thickness (CRT): Increased from 516 μm at baseline to 664.5 μm at 3 days, then decreased to 245 μm at 1 month.
  - Resolution of Fluid: Complete resolution of fluid occurred in 6 out of 7 PAEM cases (85.7%).
  - Complications: One patient developed uveal effusion and retinal ischemia.

- Discussion:
  - PAEM is common in CCH patients after PDT, likely due to the vascular nature of the tumor.
  - The appearance of IRF was more common than SRF in PAEM cases.
  - Fibrin was observed in 3 out of 7 PAEM cases.
  - PAEM typically resolves spontaneously, with most patients showing complete resolution of fluid by 1 month.
  - No standardized treatment for PAEM exists, but corticosteroids or anti-VEGF agents may help reduce recovery time.

- Conclusion:
  - PAEM is frequent in CCH patients after PDT but has a favorable prognosis with spontaneous resolution in most cases.
  - Patients should be informed about the possibility of PAEM before undergoing PDT.